Hedgehog signaling regulates FOXA2 in esophageal embryogenesis and Barrett’s metaplasia
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چکیده
منابع مشابه
Hedgehog signaling regulates FOXA2 in esophageal embryogenesis and Barrett's metaplasia.
Metaplasia can result when injury reactivates latent developmental signaling pathways that determine cell phenotype. Barrett's esophagus is a squamous-to-columnar epithelial metaplasia caused by reflux esophagitis. Hedgehog (Hh) signaling is active in columnar-lined, embryonic esophagus and inactive in squamous-lined, adult esophagus. We showed previously that Hh signaling is reactivated in Bar...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2014
ISSN: 0021-9738
DOI: 10.1172/jci66603